Marko served in the Korean War alongside his step-brother, Charles Xavier. This would-be world-conquering ape was granted extraordinary intellect and powerful psionic abilities after he and his tribe were exposed to a space-rock an alien spacecraft in the character's retconned origin that crashed into the African jungle. Shredder has appeared in all of the original TMNT videogames, often as the "boss" of the final level. He created a gas that could cancel out his spider-sense and his suit had that well-known helmet with a holographic projector and gloves armed with hallucinogenic gas. This duo eventually broke Karlo out of prison.
Uncle Sam. Victor Mancha. Though how can he forget the man who very nearly married his Aunt May?! Years later a mutant by the name of Piecemeal tried to absorb all of Proteus' dispersed energy. Death didn't stop him the first time, so why should it a second? Octopus instantly had a physical and mental impact on his foe and this encounter led to Spider-Man's first real occasion of self-doubt and fear, so shaken was Peter Parker by this encounter with a villain who truly was his match.
